譜析（上海）生物科技有限公司提供——Atypical Neuroleptics in Plasma /Serum, on-line Analysis 質(zhì)譜診斷方案
2022/3/4 17:29:25
譜析（上海）生物科技有限公司提供——Atypical Neuroleptics in Plasma /Serum, on-line Analysis 質(zhì)譜診斷方案
一、說明
The drugs olanzapine, clozapine, quetiapine, risperidone, and paliperidone (= 9-OH-risperidone) belong to the class of the so called "atypical" neuroleptics and are used for the treatment of schizophrenia. Co-medication, smoking, caffeine and food are factors that extensively influence their metabolism and thus lead to a high intraand interindividual variability of drug concentrations in blood. In order to avoid severe side effects by overdosing and to ensure an optimal therapeutic effect, therapeutic drug monitoring (TDM) is required. The RECIPE Complete Kit represents a fully automated, robust on-line SPE technique, a direct sample injection into the HPLC system.
二、產(chǎn)品優(yōu)勢
（1）Fully automated method
（2）On-line sample preparation
（3）100 % recovery
三、測試數(shù)據(jù)
Linearity: Olz/ D-Olz:
5/ 10-1000 μg/l
Clz / D-Clz:
6/5- 5000 μg/l
Qtp: 10 - 2000 μg/l
Plp, Rsp: 1 - 200 μg/l
Recovery: 100 %
LOD: 2 μg/l (Olz, Clz, D-Clz),
4 μg/I (D-Olz, Qtp)
0.4 μg/l (Plp, Rsp)
LLOQ: 5 μg/l (Olz), 6 μg/1 (Clz),
10 μg/I (D-Olz, Qtp),
4 μg/I (D-Clz)
1 μg/1 (Plp, Rsp)
Intraassay precision: 0.2 -2%
Interassay precision: 1- 6%
四、高效液相色譜參數(shù)
A: Determination of Olz, D-Olz, Clz, D-Clz, Qtp
B: Determination of Plp, Rsp
Isocratic pump 1
(SPE-buffer): flow rates: 0.5/ 1.0 ml/min
Isocratic pump 2
(mobile phase): flow rate: A: 1.3 ml/min
B: 1.0 ml/min
Switching valve: 6-port/3-channel
(order no. FK1102)
Injection volume: A: 250 μl, B: 750 μl
Injection interval: A: 22 min, B: 20 min
UV-detector: A: 254 nm, B: 280 nm
HPLC-thermostat: 30 °C
五、樣品制備
六、訂購信息
更多產(chǎn)品請(qǐng)咨詢譜析（上海）生物科技有限公司。
網(wǎng)址： haoxd.cn
電話：021-58116080
手機(jī)：17717017426 陳經(jīng)理 18019263206 陸經(jīng)理
譜析（上海）生物科技有限公司，您實(shí)驗(yàn)室試劑供應(yīng)專家，歡迎咨詢?cè)斦劇?br>
一、說明
The drugs olanzapine, clozapine, quetiapine, risperidone, and paliperidone (= 9-OH-risperidone) belong to the class of the so called "atypical" neuroleptics and are used for the treatment of schizophrenia. Co-medication, smoking, caffeine and food are factors that extensively influence their metabolism and thus lead to a high intraand interindividual variability of drug concentrations in blood. In order to avoid severe side effects by overdosing and to ensure an optimal therapeutic effect, therapeutic drug monitoring (TDM) is required. The RECIPE Complete Kit represents a fully automated, robust on-line SPE technique, a direct sample injection into the HPLC system.
二、產(chǎn)品優(yōu)勢
（1）Fully automated method
（2）On-line sample preparation
（3）100 % recovery
三、測試數(shù)據(jù)
Linearity: Olz/ D-Olz:
5/ 10-1000 μg/l
Clz / D-Clz:
6/5- 5000 μg/l
Qtp: 10 - 2000 μg/l
Plp, Rsp: 1 - 200 μg/l
Recovery: 100 %
LOD: 2 μg/l (Olz, Clz, D-Clz),
4 μg/I (D-Olz, Qtp)
0.4 μg/l (Plp, Rsp)
LLOQ: 5 μg/l (Olz), 6 μg/1 (Clz),
10 μg/I (D-Olz, Qtp),
4 μg/I (D-Clz)
1 μg/1 (Plp, Rsp)
Intraassay precision: 0.2 -2%
Interassay precision: 1- 6%
四、高效液相色譜參數(shù)
A: Determination of Olz, D-Olz, Clz, D-Clz, Qtp
B: Determination of Plp, Rsp
Isocratic pump 1
(SPE-buffer): flow rates: 0.5/ 1.0 ml/min
Isocratic pump 2
(mobile phase): flow rate: A: 1.3 ml/min
B: 1.0 ml/min
Switching valve: 6-port/3-channel
(order no. FK1102)
Injection volume: A: 250 μl, B: 750 μl
Injection interval: A: 22 min, B: 20 min
UV-detector: A: 254 nm, B: 280 nm
HPLC-thermostat: 30 °C
五、樣品制備
六、訂購信息
更多產(chǎn)品請(qǐng)咨詢譜析（上海）生物科技有限公司。
網(wǎng)址： haoxd.cn
電話：021-58116080
手機(jī)：17717017426 陳經(jīng)理 18019263206 陸經(jīng)理
譜析（上海）生物科技有限公司，您實(shí)驗(yàn)室試劑供應(yīng)專家，歡迎咨詢?cè)斦劇?br>
